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MME Marianne Weidenhaupt

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Associate Professor Grenoble-INP Phelma & Researcher @ LMGP in the IMBM group (Interfaces between Materials and Biological Matter)

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Site internet : http://

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Since 2006, I teach at the Grenoble Institute of Technology, Grenoble INP - Phelma at the Master I and II levels in the track Biomedical Engineering and in the International Master program “Nanotechnology”. I am in charge of the following subjects : Molecular Biology, Cell Biology, Immunology and Biochip technology.

Within the IMBM team, we are working at the interface between material science, electrochemistry, biochemistry and cellular biology. We have expertise in the assembly and characterization of molecular structures of various complexities at the material-electrolyte interface. We are using biophysical methods to precisely control and analyze the surfaces of our materials or the biological matter organized at the its surface. We are interested in surface adsorption, self-assembly and covalent grafting of biomacromolecules in liquid conditions.
I am particularly involved in two projects :
  • Protein adsorption and conformational changes upon contact with material surfaces.
  • Cell adhesion on material surfaces.
I yearly supervise 1-2 Master II students. Since joining LMGP-IMBM, I have co-supervised the thesis of 3 PhD students. Currently I am co supervising 2 PhD students (Karim Chouchane and Thibaut Frachon) working on insulin aggregation at material/liquid/air interfaces. TF is a Cifre fellow and his thesis emanates from a collaboration with an industrial partner, Eveon (http://www.eveon.eu/).

Most recent publications:

Bruckert F. and Weidenhaupt M. (2010) Applications of micro- and nanotechnology to study cell adhesion to material surfaces. J Adhesion Science and Technology 24, 2127-2140.

Ballet T., Boulangé L., Bréchet Y., Bruckert F. and Weidenhaupt M. (2010) Protein conformational changes induced by adsorption onto material surfaces: an important issue for biomedical applications of material science. Bulletin of the Polish Academy of Sciences – Technical Sciences 58, 303-315.

Ballet T., Bruckert F., Mangiagalli P., Bureau C, Boulangé L, Nault L., Perret T. and Weidenhaupt M. (2012) DnaK prevents human insulin amyloid fiber formation on hydrophobic surfaces. Biochemistry, 51, 2172−2180.

Pandey LM, Le Denmat S, Delabouglise D, Bruckert F, Pattanayek SK and Weidenhaupt M. (2012) Surface chemistry at the nanometer scale influences insulin aggregation. Colloids Surf B Biointerfaces, 100, 69-76.

Nault L, Guo P, Jain B, Bréchet Y, Bruckert F and Weidenhaupt M. (2013) Human insulin adsorption kinetics, conformational changes and amyloidal aggregate formation on hydrophobic surfaces. Acta Biomater. 9(2), 5070-5079.

Nault L, Vendrely C, Bréchet Y, Bruckert F and Weidenhaupt M. (2013) Peptides that form β-sheets on hydrophobic surfaces accelerate surface-induced insulin amyloidal aggregation. FEBS Letters, 587, 1281–1286.

Nguyen U, Grekov D, Geiselmann J, Stambouli V, Weidenhaupt M and Delabouglise D (2014) Anodic deposit from respiration metabolic pathway of Escherichia coli. Electrochimica Acta 130, 200–205.

Dalonneau F, Liu XQ, Sadir R, Almodovar J, Mertani HC, Bruckert F, Albiges-Rizo C, Weidenhaupt M, Lortat-Jacob H, Picart C (2014) The effect of delivering the chemokine SDF-1α in a matrix-bound manner on myogenesis. Biomaterials 35(15), 4525-4535.

Activités / CV

Born 10th July 1967 in Esch-sur-Alzette (Luxembourg)
Nationality : luxembourgish

Education at the Swiss Federal Institute of Technology (ETH) in Zurich
1986-1991     ETH Diploma in Natural Sciences (Microbiology, Genetics, Cell Biology,
                      Immunology, Plant Physiology)
1995               PhD in Natural Sciences

                      Thesis director : Prof. Dr. Hauke Hennecke
                      Subject: In the search for new NifA-dependent genes and their function in Bradyrhizobium japonicum
  Postdoctoctoral postions
1995 - 2002   at CEA-Grenoble (France)
2002 - 2006   at EMBL-Grenoble (France)

Since 2006, Associate professor at Grenoble INP - Phelma (Molecular and Cell Biology, Immunology, Biosensors), where I am also in charge of  :
  • International Relations G-INP - Phelma Biomedical Engineering
Since 2008, I am responsible for international exchanges of students from and to Phelma in Biomedical Engineering. I am in charge of establishing contacts with partner universities in my field of expertise. I advise Phelma students for academic exchanges abroad and coordinate the stay of incoming exchange students at our university.
  • The Biotech facility at CIME Nanotech
Since 2006, I am co-responsible for the Biotech facility of the “Centre interuniversitaire de microélectonique et nanotechnologies” (CIME Nanotech). This facility is equipped with state-of-the-art techniques to isolate, purify and characterize nucleic acids and proteins as well as cultivating and imaging pro- and eukaryotic cells.  The facility hosts yearly an average of 6000 student-hours originating from different universities and educational programs.

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Rédigé par Marianne Weidenhaupt

mise à jour le 14 mars 2017

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Communauté Université Grenoble Alpes
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