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Seminar LMGP - 10/12/2015 - Dr Florence Ruggiero

Published on November 10, 2015
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Seminar December 10, 2015
14:00 - 2ème étage - salle de séminaire - Laboratoire LMGP
Grenoble INP - Phelma
3 parvis Louis Néel - 38000 Grenoble
Accès : TRAM B arrêt Cité internationale
Free entrance - No registration
 

Collagen networks : more than just a scaffold

Dr Florence Ruggiero - Director of Resarch at CNRS at the Functional Genomics of Lyon (IGFL)

Collagens are the major components of the extracellualr matrix and the most abundant vertebrate proteins. They form a superfamily of 28 members that show a remarkable diversity in molecular and supramolecular organization, and tissue distribution. In addition to be necessary for matrix structure and dynamics, they are involved in a variety of cell and morphogenetic events and display highly specialized conserved functions. Mutations in human collagen genes are responsible for a dozen of disorders that affect various organs and tissues. Collagens can no longer be considered just as structural proteins that provide strength to tissues. We investigate mechanisms underlying the diverse and complex functions of collagens in development and disease, from molecules to organisms. Examples of our recent work, as the role of unconventional collagens in the zebrafish neuromuscular system, will be presented.


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Date of update November 22, 2015

Univ. Grenoble Alpes