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Seminar LMGP - 26/09/2017 - Vincent FITZPATRICK

Published on August 28, 2017
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Seminar September 26, 2017
Grenoble INP - Phelma
Laboratoire LMGP
3 parvis Louis Néel - 38000 Grenoble
Accès : TRAM B arrêt Cité internationale
Free entrance - No registration
2:00 pm - 2nd floor - seminar room

Using micropatterns of BMP-2 and fibronectin to recreate the stem cell niche

vincent.jpg

vincent.jpg

Vincent Fitzpatrick - PhD Student, LMGP

 

Abstract

In vivo, stem cells reside within a niche microenvironment which regulates at a highly localized level both self-renewal and differentiation. This occurs through cell-cell interactions, the action of growth factors, and the properties of the extracellular matrix. Recreating the stem cell niche in vitro is a crucial aspect in understanding how the microenvironment controls stem cell behavior. Here we used microcontact printing to generate micropatterns of growth factors (BMP-2) and extracellular matrix proteins (Fibronectin) on a soft biomimetic films, and thus recreate a simplified niche model to study the factors influencing osteoblastic differentiation.
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Date of update September 15, 2017

Univ. Grenoble Alpes