Our initial studies showed that bone morphogenetic proteins (BMPs) can be presented to cells in a matrix-bound mannerr via a biomaterial surface (Crouzier et al, Small 2009) . This biomaterial is a biomimetic film, made by self-assembly of polysaccharides and polypeptides, which can trap the BMPs.
We then proved that 1) BMP-coated ceramic granules are osteoinductive in an ectopic site when implanted in rat muscle (Guillot et al, Biomaterials 2011) 2) BMP-2-loaded film-coated titanium implants can be dried and sterlized while remaining osteoinductive (Guillot et al, Biomaterials 2013) . In 2016, we showed that a critical size femoral bone defect in rats can be regenerated by combining an initially empty 3D polymeric scaffold made of to the osteoinductive film coating. The newly formed bone contained cortical and trabecular bones and it was vascularized (Bouyer et al, Biomaterials 2016).
In collaboration with Prof. Georges Bettega (CHR Annecy and IAB Grenoble), we are continuing our pre-clinical developments in large animals in the frame of the ERC POC REGENERBONE (PI CPicart) , Fondation Gueules Cassées and ANR OBOE 2019-2022 (PI CPicart).