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Physico chemistry of solids, thin films, biotechnologies
Applications for micro & nano- technologies, energy, health ...

> Research > IMBM

Bone tissue engineering

OBJECTIVES

Our initial studies (Crouzier et al, Small 2009) have shown that potent osteoinductive growth factors of the BMP family (Bone Morphogenetic Proteins) can be loaded in tunable amounts in layer-by-layer films made of biopolymers. We have now taken two complementary routes: the first one consists in investigating the signaling mechanisms of BMP proteins presented in a "matrix-bound" manner by the biomaterial; the second route aims at coating BMP-loaded films onto implants that are commonly used in orthopedic, dental and maxillo-facial surgery to enhance their osteoinductive properties.

Researchers

Catherine Picart
Thomas Boudou


Group Members

   Amy Wagoner Johnson (Visiting associate Pr.)
   Hong Li (Post-doc)
   Vincent Fitzpatrick (PhD student)
   Emeline Bourgeois (PhD student)
   Anne Valat (PhD student)
   Michael Bouyer? (PhD student)?
   Ana Catarina Quintal (Master student)
   Cedric Plettinx (Master student)

Selected Publications

Spatio-temporal control of LbL films for biomedical applications: from 2D to 3D.
Monge C, Almodóvar J, Boudou T, Picart C.
Adv. Healthc. Mater. 2015.
Spatial patterning of BMP-2 and BMP-7 on biopolymer films and the guidance of muscle cell fate. 
Almodovar J, Guillot R, Monge C, Vollaire J, Seilimovic S, Coll JL,
Khademhosseini A, Picart C.
Biomaterials. 2014.
The stability of BMP loaded polyelectrolyte multilayer coatings on titanium.
Guillot R, Gilde F, Becquart P, Sailhan F, Lapeyrere A, Logeart-Avramoglou D, 
Picart C.
Biomaterials. 2013.
Secondary structure of rhBMP-2 in a protective biopolymeric carrier material.
Gilde F, Maniti O, Guillot R, Mano JF, Logeart-Avramoglou D, Sailhan F, Picart C.
Biomacromolecules. 2012.
The performance of BMP-2 loaded TCP/HAP porous ceramics with a polyelectrolyte multilayer film coating.
Crouzier T, Sailhan F, Becquart P, Guillot R, Logeart-Avramoglou D, Picart C.
Biomaterials. 2011.
Presentation of BMP-2 from a soft biopolymeric film unveils its activity on cell adhesion and migration.
Crouzier T, Fourel L, Boudou T, Albiges-Rizo C, Picart C. 
Adv. Mat. 2011.

mise à jour le 3 novembre 2017

Univ. Grenoble Alpes