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Physico chemistry of solids, thin films, biotechnologies
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> Research > IMBM

Tissue Biomimetism

OBJECTIVES

Our goal is to engineer biomimetic surfaces to mimic some features of the natural extracellular matrices, notably their biochemical and physical properties. Using these well-controlled surfaces, we study in vitro the cellular processes guiding tissue formation, including cell signaling. Our team has an expertise in glycosaminoglycans (GAG, such as heparan sulfates, hyaluronic acid) and in bone morphogenetic proteins (BMPs), which are playing a role in a large number of physiological and pathological processes. 
- The first research topic focuses on 2D platforms made of streptavidin to bind heparan sulfate, cell adhesive ligands and BMPs.
- The second research topic focuses on biomimetic films made by the layer-by-layer assembly .
Using several biophysical techniques (QCM, spectroscopic ellipsometry) that are surface-sensitive, we can precisely control the functionalization of the biomimetic surfaces and quantify molecular interactions. 
Funding: Team Fondation Recherche Medicale,  ANR CODECIDE (PI Corinne ALBIGES-RIZO, IAB Grenoble), IDEX IRS (IDEX University Grenoble Alpes), SATT Bioactivecoatings

Researchers and Technical Staff

Elisa Migliorini (CNRS Researcher)
Catherine Picart (CEA Research Director)
Paul Machillot (CNRS Assistant Engineer)
Laura Clauzier (Research Engineer, Grenoble INP, CDD)

Alumni

Jean Le Pennec (M2 student, 2019)
Simon Peyras (M1 student, 2018)
Vincent Fitzpatrick (PhD student, 2014-2017)
Quentin Lubart (PhD student, 2013-2016)
Anne Valat (PhD student, 2013-2016)
Flora Gilde (PhD student, 2011-2014)
 

Paper accepted in Biointerphases: Migliorini E et al. Dec 2018

 

Spectroscopic ellipsometry and QCM-D to calculate mass adsorptionPractical guide to characterize biomolecule adsorption on solid surfaces (Review)

Elisa Migliorini, Marianne Weidenhaupt, and Catherine Picart






 

IDEX-IRS funding 2018–2021

PhD position for Julius Sefkow-Werner starting in October 2018

Welcome Julius

Welcome Julius Julius Sefkov-Werner M2 student

E. Migliorini oral presentation award


Best oral presentation at Proteoglycan conference, Varese, Italy

Enhanced biological activity of BMP-2 bound to surface-grafted heparan sulfate.
Elisa Migliorini*, Patrick Horn, Tamás Haraszti, Seraphine V. Wegner, Christian Hiepen,
Petra Knaus, Ralf P. Richter and E. Ada Cavalcanti-Adam*

Adv. Biosys. 2017, 1600041.
DOI: 10.1002/adbi.201600041


  The mode of chemokine CXCL12α presentation determines myoblast adhesion and motility.
Thakar Dhruv, Dalonneau Fabien, Migliorini Elisa, Lortat-Jacob Hugues, Boturyn Didier,  Coche-Guerente Liliane, Picart Catherine  and Richter Ralf P. Biomaterials. 2017;123:24-38. doi.org/10.1016/j.biomaterials.2017.01.022



Tuning cellular responses to BMP-2 with material surfaces.
Migliorini Elisa, Valat Anne, Picart Catherine, Cavalcanti-Adam Elisabetta Ada. CGFR. 2016;27:43-54. doi: 10.1016/j.cytogfr.2015.11.008

Date of update November 8, 2019

Univ. Grenoble Alpes