Contact : Catherine Picart Ezrin, member of the ezrin/radixin/moesin (ERM) family, is a membrane cytoskeleton linker involved in the cellular morphogenesis and motility. Ezrin switches dynamically between the cytosol where it is under a dormant state and the membrane, once activated (open conformation). The activation process requires its interaction with a specific lipid, phosphatidylinositol-4,5-bisphophate (PIP2) and/or phosphorylations at specific sites. The membrane-associated ezrin can then interact with the actin cytoskeleton.
The aim of our project is to understand at the molecular level the link between membrane structures and the actin cytoskeleton.
We study in vitro using recombinant proteins the interplay between PIP2, ezrin and actin in biomimetic systems in order to get a better knowledge of the underlying important molecular processes.
The biomimetic systems cover a large range of sizes and shapes : large unilamelar vesicles (LUVs), supported lipid bilayers (SLBs) and giant unilamellar vesicles (GUVs). Selected Publications
mise à jour le 7 avril 2012