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LMGP Seminar : Shai Rahimipour - Surface-Modified Proteinous Microspheres

Published on July 2, 2013
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Conference July 24, 2013
Wednesday at 2:00 pm - LMGP Conference room - 2nd floor
LMGP / Grenoble INP Minatec
3 parvis Louis Néel - Grenoble 
Accès : Tram B - Cité Internationale

Free entrance - No registration required  
Rahimipour.jpg

Rahimipour.jpg

Shai Rahimipour, Ph.D.
Senior Lecturer, Department of Chemistry - Bar-Ilan University (Israel)

Surface-Modified Proteinous Microspheres and Self-assembled Cyclic D,L-alpha-Peptides as Potential Therapeutics for Alzheimer's Diseases

Abstract
Protein misfolding and aggregation is the fundamental cause of many amyloidogenic diseases. The deposition of proteins in the form of amyloid fibrils and plaques is the characteristic feature of more than 20 degenerative conditions affecting either the central nervous system or a variety of peripheral tissues. For Alzheimer's disease (AD), the oligomerization of amyloid beta (Aß) to soluble oligomers and their accumulation in the brain are believed to be the primary pathogenic events that lead to synaptic loss and selective neuronal cell death. Therefore, reducing Aß levels in the brain by recruiting the immune system or inhibiting Aß aggregation via agents that interfere with its self-assembly are promising strategies for AD therapy. In this presentation, I will describe our recent efforts in developing surface-modified proteinous microspheres that can selectively bind Aß, enhance its clearance by macrophages and reduce its toxicity. I will also describe the development of novel self-assembled cyclic D,L-a-peptide nano-architectures that interact strongly with A and inhibit its aggregation and toxicity due to their immense structural-functional similarities to that of different amyloids. The in vitro and mechanistic studies of these kinds of peptide architectures will be also discussed.
References

(1) Richman, M.; Wilk, S.; Chemerovski, M.; Warmlander, S. K.; Wahlstrom, A.; Graslund, A.; Rahimipour, S.
In Vitro and Mechanistic Studies of an Anti-Amyloidogenic Self-Assembled Cyclic D,L-a-Peptide Architecture. J. Am. Chem. Soc. 2013, 135, 3474.
(2) Richman, M.; Perelman, A.; Gertler, A.; Rahimipour, S.
Effective targeting of abeta to macrophages by sonochemically prepared surface-modified protein microspheres. Biomacromolecules 2013, 14, 110.
(3) Richman, M.; Wilk, S.; Skirtenko, N.; Perelman, A.; Rahimipour, S.
Surface-modified protein microspheres capture amyloid-beta and inhibit its aggregation and toxicity. Chem. Eur. J. 2011, 17, 11171.

Brief CV
He did his PhD thesis work in the Department of Organic Chemistry and Neurobiology, at the Weizmann Institute of Science, Israel and he was graduated in 2001.
During his second post-doc at the Scripps Research Institute in California (2003-20006),he worked on Self-assembled cyclic D,L-a-peptide and cyclic D,L-a-glycopeptides nanotubes as antibacterial and anticancer agents.

In 2006, he became a Senior Lecturer in  Bar-Ilan University's Department of Chemistry.
Main fields of research : Neurodegenerative diseases (Multiple Sclerosis, Alzheimer's Disease, Parkinson's Disease), supramolecular chemistry, Peptide Chemistry, Combinatorial Chemistry, Drug design
More info on Dr. Rahimipour's Lab

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Date of update July 3, 2013

  • Tutelle CNRS
  • Tutelle Grenoble INP
Univ. Grenoble Alpes