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Synthèse et propriétés de monocristaux, de poudres, films minces ou hétérostructures

Etudes à l'interface avec la matière biologique

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LMGP seminar - V. GRIBOVA- Materials for regeneration of skeletal muscle: an interdisciplinary approach

Published on March 29, 2013
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Conference from May 7, 2013 to May 8, 2013
Tuesday at 2:00 pm - LMGP Conference room - 2nd floor
LMGP / Grenoble INP Minatec
3 parvis Louis Néel - Grenoble 
Accès : Tram B - Cité Internationale

Free entrance - No registration required  
Varvara GRIBOVA

Varvara GRIBOVA

Varvara GRIBOVA
PhD student in IMBM/LMGP - Supervisors: Catherine Picart (LMGP) and Rachel Auzély (CERMAV)

Materials for regeneration of skeletal muscle: an interdisciplinary approach

Abstract

Tissue engineering consists in association of cells and biocompatible materials to create artificial tissues. This approach presents an alternative to the whole organ transplantation and has a potential to solve the problem of the shortage of organs available for donation.
To create new tissues in a laboratory, the development of new materials mimicking the natural environment of the cells is required. In this context, collaboration between the scientists from different disciplines (biology, chemistry, materials science) becomes necessary.
My project is focused on the development of the substrates that mimic skeletal muscle environment. We use polyelectrolyte multilayer films as a biomimetic substrate. These thin films (~100 nm) are made of polypeptides using layer-by-layer assembly method. They can be further functionalized by covalent grafting of bioactive peptides and their stiffness can be modulated by chemical cross-linking.

 

Biomimetic films - Gribova



Figure. Construction of biomimetic films with tunable mechanical and biochemical properties for the control of cellular processes.

Such substrates have a potential to control muscle stem cell behavior and produce functional muscle tissue. Muscle tissues created in the laboratory can be used for muscle repair after an injury and for the treatment of muscle diseases, but are also required for pharmaceutical assays and for fundamental studies of muscle development.
This presentation will emphasize the role of materials for solving current problems in biological science and the importance of interdisciplinary collaboration.

 Brief CV

 

 

Varvara Gribova (born in 1985 in Vilnius, Lithuania) received a Master's degree in Cellular and Molecular Biology from the University of Pierre and Marie Curie in Paris.
Since 2010 she is a PhD student in LMGP (Grenoble Institute of Technology & CNRS) and CERMAV (CNRS) laboratories working under direction of Pr Catherine Picart and Pr Rachel Auzély-Velty. Her PhD project consists in designing biomimetic polyelectrolyte multilayer films for the control of muscle  cell adhesion and differentiation.

 


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Date of update May 5, 2014

  • Tutelle CNRS
  • Tutelle Grenoble INP
Univ. Grenoble Alpes