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Synthèse et propriétés de monocristaux, de poudres, films minces ou hétérostructures

Etudes à l'interface avec la matière biologique

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Nouvelle publication IMBM d'Anne Valat

Publié le 25 janvier 2016
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Communiqué 25 janvier 2016

Congratulations Anne Valat! Her new review on tuning cellular responses to BMP-2 with material surfaces is published in Cytokine & Growth Factor Reviews!

Migliorini et al., abstract fig.jpg

Migliorini et al., abstract fig.jpg

Here is Anne's paper and here is the abstract:
Bone morphogenetic protein 2 (BMP-2) has been known for decades as a strong osteoinductive factor and for clinical applications is combined solely with collagen as carrier material. The growing concerns regarding side effects and the importance of BMP-2 in several developmental and physiological processes have raised the need to improve the design of materials by controlling BMP-2 presentation. Inspired by the natural cell environment, new material surfaces have been engineered and tailored to provide both physical and chemical cues that regulate BMP-2 activity. Here we describe surfaces designed to present BMP-2 to cells in a spatially and temporally controlled manner. This is achieved by trapping BMP-2 using physicochemical interactions, either covalently grafted or combined with other extracellular matrix components. In the near future, we anticipate that material science and biology will integrate and further develop tools for in vitro studies and potentially bring some of them toward in vivo applications.
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mise à jour le 25 janvier 2016

  • Tutelle CNRS
  • Tutelle Grenoble INP
Univ. Grenoble Alpes