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Synthèse et propriétés de monocristaux, de poudres, films minces ou hétérostructures

Etudes à l'interface avec la matière biologique
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Papier d'Adria Sales

Publié le 10 février 2019
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Communiqué du 10 janvier 2019 au 29 mars 2019

Le papier "Age-dependent migratory behavior of human endothelial cells revealed by substrate icrotopography" a été publié dans Experimental Cell Researchs

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Ici  vous trouverez le papier d'Adria Sales
"Cell migration is part of many important in vivo biological processes and is influenced by chemical and physical factors such as substrate topography. Although the migratory behavior of different cell types on structured substrates has already been investigated, up to date it is largely unknown if specimen's age affects cell migration on structures. In this work, we investigated age-dependent migratory behavior of human endothelial cells from young (≤ 31 years old) and old (≥ 60 years old) donors on poly(dimethylsiloxane) microstructured substrates consisting of well-defined parallel grooves. We observed a decrease in cell migration velocity in all substrate conditions and in persistence length perpendicular to the grooves in cells from old donors. Nevertheless, in comparison to young cells, old cells exhibited a higher cell directionality along grooves of certain depths and a higher persistence time. We also found a systematic decrease of donor age-dependent responses of cell protrusions in orientation, velocity and length, all of them decreased in old cells. These observations lead us to hypothesize a possible impairment of actin cytoskeleton network and affected actin polymerization and steering systems, caused by aging."


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mise à jour le 10 février 2019

  • Tutelle CNRS
  • Tutelle Grenoble INP
Univ. Grenoble Alpes