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Grenoble INP
Physico chemistry of solids, thin films, biotechnologies
Applications for micro & nano- technologies, energy, health ...

New conference paper!

Published on August 1, 2015
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August 21, 2015

Congratulations Benoît Kalman! His work on engineering human muscle microtissues has been selected for an oral presentation.

Kalman_CMBBE_15.jpg

Kalman_CMBBE_15.jpg

Benoit's work has been selected for a talk at the 40th congress of the French Society of Biomechanics and the proceedings have been published in CMBBE.

Actual in vitro models for skeletal muscle tissue engineering present many limitations for high content screening analysis: 2D models do not mimic the native cellular microenvironment, whereas 3D models require large amounts of cells, thus limiting the reproducibility of experiments. In our lab, we developed a microfabricated platform that enables the generation of arrays of 3D microtissues from low cell number while precisely controlling a large number of parameters, such as extracellular matrix composition, substrate rigidity, electrical or biochemical stimulations. Furthermore, this platform also allows to follow in real time microtissues contraction or calcium dynamics, as well as myoblast differentiation toward myotubes. Here, we demonstrate how tissue formation, stability, and cell differentiation in microtissues generated from immortalized human myoblasts can be improved by co-culturing the myoblasts with fibroblasts.


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Written by Thomas Boudou

Date of update September 17, 2015

Communauté Université Grenoble Alpes