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Physico chemistry of solids, thin films, biotechnologies
Applications for micro & nano- technologies, energy, health ...

New paper by Sarah Delshadi

Published on April 10, 2017
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Communique from March 31, 2017 to April 6, 2017

The paper "Rapid immunoassay exploiting nanoparticles and micromagnets: proof-of-concept using ovalbumin model" has been pub lished in Bioanalysis

magia.PNG

magia.PNG

Here you will find the paper by  Sarah. This is the abstract:
"We present a fast magnetic immunoassay, combining magnetic nanoparticles and micromagnets. High magnetic field gradients from micromagnets are used to develop a new approach to the standard ELISA. Materials & methods/results: A proof-of-concept based on colorimetric quantification of antiovalbumin antibody in buffer is performed and compared with an ELISA. After optimization, the magnetic immunoassay exhibits  a limit of detection (40 ng/ml) and a dynamic range (40–2500 ng/ml) similar to that of ELISAs developed using same biochemical tools.
Conclusion: Micromagnets can be fully integrated in multiwell plates at low cost to allow the efficient capture of immunocomplexes carried by magnetic nanoparticles. The method is generic and permits to perform magnetic ELISA in 30 min.

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Written by Maria Carmen Jimenez Arevalo

Date of update April 10, 2017

Communauté Université Grenoble Alpes
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