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Physico chemistry of solids, thin films, biotechnologies
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Paper by Franz Bruckert 2017

Published on November 30, 2017
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Communique from December 7, 2017 to December 21, 2017

The paper "Diamagnetically trapped arrays of living cells above micromagnets" has been published in Lab on a Chip

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Here  you will find the paper by Franz Bruckert

"Cell arrays are of foremost importance for many applications in pharmaceutical research or fundamental biology. Although arraying techniques have been widely investigated for adherent cells, organization of cells in suspension has been rarely considered. The arraying of non-adherent cells using the diamagnetic repulsive force is presented. A planar arrangement of Jurkat cells is achieved at the microscale above high quality microfabricated permanent magnets with remanent magnetization of Jr ≈ 1 T, in the presence of a paramagnetic contrast agent. The cytotoxicity of three Gd based contrast agents, Gd-DOTA, Gd-BOPTA and Gd-HP-DO3A, is studied. Among them, Gd-HP-DO3A appears to be the most biocompatible toward Jurkat cells. In close agreement with analytical simulations, diamagnetically ‘suspended’ cells have been successfully arrayed above square and honeycomb-like micromagnet arrays, which act as a “diamagnetophobic” surface. Living cell trapping is achieved in a simple manner using concentrations of Gd-HP-DO3A as low as 1.5 mM."

 



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Written by Maria Carmen Jimenez Arevalo

Date of update November 30, 2017

Communauté Université Grenoble Alpes
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