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Grenoble INP
Synthèse et propriétés de monocristaux, de poudres, films minces ou hétérostructures

Etudes à l'interface avec la matière biologique

Self-assembly of proteins on material surfaces

THERAPEUTIC PROTEIN AGGREGATION AT MATERIAL SURFACES

We have developed sensitive biochemical and biophysical techniques to study protein adsorption and aggregation kinetics in a quantitative and qualitative way on the material surface. Our model protein is insulin and its material-induced aggregation into amyloid fibers. More recently, we are also analyzing the effect of dynamic air-liquid interfaces on protein aggregation. (more info).

PROTEIN INTERACTIONS WITH BIOMIMETIC MEMBRANES

Ezrin and Moesin, members of the ezrin/radixin/moesin (ERM) family, are membrane/cytoskeleton linkers involved in cell morphogenesis and motility. The aim of this project is to understand at the molecular level the link between membrane structures and the actin cytoskeleton.  To this end, we produce recombinant ERM proteins and engineer biomimetic lipid membranes. (more info).
 

Written by Thomas Boudou

Date of update March 11, 2015

Communauté Université Grenoble Alpes
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